The match kicks off at 19H30.
The People's Team head into this game on the back of a 5-0 defeat to Bloemfontein Celtic and will be ultra determined to get back into winning form against Celtic's neighbours, Free State Stars.
Stars themselves head into this game with a confidence-boosting 2-0 win over Maritzburg United in the Telkom Cup under their belts.
Striker Diyo Sibisi reminded the South African soccer fraternity of his prowess in front of goal with a brace and he will need to be carefully monitored.
Fellow striker Stembiso Ngcobo is another player who will need to watched - although the former Durban Stars striker is yet to find his scoring touch in the PSL, he was prolific with Stars in the first division and has already represented Bafana Bafana.
Nigerian midfielder Prince Olomu is another quality player, and if allowed to, can dictate matters from the middle of the park and weigh in with a few goals of his own.
Santos are also likely to come up one of their former players in left-sided utility-man Ruben Cloete.
The match will be the first Premiership fixture in charge for Ea Lla Koto coach Themba Sithole, who has taken over from Owen Da Gama.
Santos coach David Bright will need no reminding of the fact that Stars can be formidable opponents when on song - his first game in charge of The People's Team last season saw his side being hammered 4-1.
But Bright has come a long way since then and will be looking to mastermind a Santos victory, which would be their first since the 2-0 win over Bay United on September 12.
Stars' only win in the league this season has also come at the expense of the Port Elizabeth team, whom they beat 3-2.
Both teams currently have four points in the league - Stars occupy ninth position and Santos are 11th on the Absa Premiership table.
